Abstract: . . .  longe conscutive. Ils ont appel ce phnomne prconditionnement (traduit de langlais preconditioning ). Tout se passe comme si le myocarde qui vient de subir une ou plusieurs ischmies brves garde la mmoire de cette agression et met en jeu des mcanismes endognes qui lui per- mettront de mieux tolrer une isch- mie prolonge venir. 352 SYNTHSE mdecine/sciences 1999 ; 15 : 352-8 m/s n3, vol.15, mars 99 Le prconditionnement: adaptation du cardiomyocyte l ischmie De brefs pisodes ischmiques rpts prcdant une isch- mie prolonge rduisent de faon importante ltendue de la zone myocardique infarcie. Cette protection endogne, appele prconditionnement, peut tre considre comme un traitement adjuvant de la reperfusion myocardique. Plu- sieurs mdiateurs responsables de linduction du prcondi- tionnement ont t identifis et lensemble des tudes . . .
. . .  1994; 28: 1285-91. 40. Speechly-Dick ME, Grover GJ, Yellon DM. Does ischemic preconditioning in the human involve protein kinase C and ATP-dependent K + channel? Studies of contractile function after simulated ischemia in an atrial in vitro model. Circ Res 1995; 77: 1030-5. 41. Yellon DM, Alkhulaifi A, Pugsley WB. Preconditioning the human heart. Lancet 1993; 342: 276-7. 42. Deutsch E, Berger M, Kussmaul WG, et al. Adaptation to ischemia during percuta- neous transluminal coronary angioplasty. Clinica, hemodynamic, and metabolic fea- tures. Circulation 1990; 82: 2044-51. 43. Tomai F, Crea F, Gaspardone A, et al . Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K + channel blocker. Circulation 1994; 90: 700-5. 44. Ovize M, Kloner RA, Hale SH, Przyklenk K. Coronary cyclic flow . . .
. . .  and the activation of pro- tein kinase C. This cardioprotec- tion is not limited to the heart but can affect many other organs. Recent evidence suggests that it may also apply to the human heart, especially during cardiac surgery, coronary angioplasty or in the cli- nical settings of pre-infarction angina. TIRS PART M. Ovize. 39. Ikonomidis JS, Tumiati LC, Weisel RD, Mickle DA, Li RK. Preconditioning human ventricular cardiomyocytes with brief per- iods of simulated ischemia. Cardiovasc Res 1994; 28: 1285-91. 40. Speechly-Dick ME, Grover GJ, Yellon DM. Does ischemic preconditioning in the human involve protein kinase C and ATP-dependent K + channel? Studies of contractile function after simulated ischemia in an atrial in vitro model. Circ Res 1995; 77: 1030-5. 41. Yellon DM, Alkhulaifi A, Pugsley WB. Preconditioning the human heart. Lancet . . .
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