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Abstract: . . . and in combination, on guinea pig ventricular my- ocytes. J Pharm Exp Therap 1999;289:156165. 12. Shinagawa K, Shiroshita-Takeshita A, Schram G, Nattel S. Effects of antiarrhythmic drugs on fibrillation in the remod- eled atrium: Insights into the mechanism of amiodarones superior efficacy. Circulation 2003;107:14401446. . . . . . . maintain sinus rhythm post-cardioversion in AF patients. Electrical remodeling is a process whereby rapid atrial activation, as occurs during AF, alters atrial electrophysiology to promote AF main- tenance and to increase atrial vulnerability to AF in- duction by premature atrial beats [2]. Atrial refractory period abbreviation is a central feature of atrial . . . . . . 9. Van Noord T, Van Gelder IC, Tieleman RG, et al. VER- DICT: The verapamil versus digoxin cardioversion trial: A randomized study on the role of calcium lowering for mainte- nance of sinus rhythm after cardioversion of persistent atrial fibrillation . J Cardiovasc Electrophysiol 2001;12:766769. 10. Bertaglia E, Deste D, Zanocco A, et al. Effects of pretreat- ment . . . . . . alone and in combination, on guinea pig ventricular my- ocytes. J Pharm Exp Therap 1999;289:156165. 12. Shinagawa K, Shiroshita-Takeshita A, Schram G, Nattel S. Effects of antiarrhythmic drugs on fibrillation in the remod- eled atrium: Insights into the mechanism of amiodarones superior efficacy. Circulation 2003;107:14401446. . . . . . . thepreventionofAFrecurrence,andclearlyshowsthat diltiazem is ineffective. It also clearly shows that amio- darone is quite effective in promoting both successful electrical rhythm reversion and sinus rhythm mainte- nance in AF patients, and evaluates the potential un- derlying mechanisms with the use of repeated electro- physiological study, Holter monitoring and . . . . . . fibrillation : A randomised study. Heart 2001;85:578580. 11. Bosch RF, Li GR, Gaspo R, Nattel S. Electrophysiologic effects of chronic amiodarone therapy and hypothyroidism, alone and in combination, on guinea pig ventricular my- ocytes. J Pharm Exp Therap 1999;289:156165. 12. Shinagawa K, Shiroshita-Takeshita A, Schram G, Nattel S. Effects of antiarrhythmic drugs . . . --2371,6,198,2739,11855
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