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Abstract: . . . Verheule S, van Batenburg CA, Coenjaerts FE, Kirchhoff S, Willecke K, Jongsma HJ: Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40. J Cardiovasc Electrophysiol 1999;10:13801389. 28 Lamarche J, OHara G, Philippon F, Gilbert M, Daleau P: Molecular analysis of connexin 40 in the familial form of atrial fibrillation . Eur Heart J 2001;22:15111512. . . . . . . LL, Roberts R, Hassan AS: Identification of a gene respon- sible for familial Wolff-Parkinson-White syn- drome. N Engl J Med 2001;344:18231831. 23 Gollob MH, Seger JJ, Gollob TN, Tapscott T, Gonzales O, Bachinski L, Roberts R: Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and con- duction system disease with childhood onset and absence of cardiac hypertrophy. Circula- tion 2001;104:30303033. 24 Robinson K, Frenneaux MP, Stockins B, Kara- tasakis G, Poloniecki JD, McKenna WJ: Atrial fibrillation . . . . . . KvLQT1, minK, and two unknown genes at chromosome 6q1416 and 10q2224. These studies not only provide insight into the molecular genetic basis of atrial fibrillation but also suggest some possible pathophysiologic mechanisms in atrial fibrillation . We hope that genetic studies can lead to the discovery of new therapeutic targets for a more effective treatment of atrial fibrillation . References 1 Kannel WB, Abbott RD, Savage DD, et al: Epi- demiologic features of atrial fibrillation . N Engl J Med 1982;306:10181022. . . . . . . Willecke K, Jongsma HJ: Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40. J Cardiovasc Electrophysiol 1999;10:13801389. 28 Lamarche J, OHara G, Philippon F, Gilbert M, Daleau P: Molecular analysis of connexin 40 in the familial form of atrial fibrillation . Eur Heart J 2001;22:15111512. . . . . . . Jongsma HJ: Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40. J Cardiovasc Electrophysiol 1999;10:13801389. 28 Lamarche J, OHara G, Philippon F, Gilbert M, Daleau P: Molecular analysis of connexin 40 in the familial form of atrial fibrillation . Eur Heart J 2001;22:15111512. . . . --3000,5,300,2720,26367
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