Abstract: . . .  Hematol 2004;75: 40-47. 21. Lee P, Chen W, Ng W, et al. Low-dose aspirin increases aspirin resistance in patients with coronary artery disease. Am J Med 2005; 118:723-727. Table 6 Incidence of Major Bleeding During Aspirin Therapy 20 Dose (mg/day) No. patients Rate 95% CI 100 13 337 1.7% 1.4-1.9% 100-325 43 489 1.7% 1.5-1.8% 325 1409 2.5% 1.7-3.3% 202  . . .
. . .  placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke. Lancet 1997;349:1641-1649. 19. Nelson MR, Liew D, Bertram M, et al. Epidemiological modelling or routine use of low dose aspirin for the primary prevention of coronary heart disease and stroke in those aged 70. BMJ 2005;330:1306- 1311. 20. Serebruany VL, Malinin AI, Eisert RM, et al. Risk of bleeding com- plications with antiplatelet agents: meta-analysis of 338 191 . . .
. . .  aspirin use in 20 000 patients with acute ischaemic stroke. Lancet 1997;349:1641-1649. 19. Nelson MR, Liew D, Bertram M, et al. Epidemiological modelling or routine use of low dose aspirin for the primary prevention of coronary heart disease and stroke in those aged 70. BMJ 2005;330:1306- 1311. 20. Serebruany VL, Malinin AI, Eisert RM, et al. Risk of bleeding com- plications with antiplatelet agents: meta-analysis of 338 191 patients enrolled in 50 . . .
. . .  Therapy 3 Daily Dose (mg) Relative Risk 95% Confidence Interval 75 1.7 0.8 to 3.3 75-150 1.5 1.0 to 2.3 160-325 1.4 1.0 to 2.0 201 Dalen Aspirin to Prevent Heart Attack and Stroke Page 5 those taking 100 mg versus those taking 100 to 325 mg of aspirin per day. It should be noted that the incidence of minor bleeding was clearly related to aspirin dose. The  . . .
. . .  heart disease and stroke in those aged 70. BMJ 2005;330:1306- 1311. 20. Serebruany VL, Malinin AI, Eisert RM, et al. Risk of bleeding com- plications with antiplatelet agents: meta-analysis of 338 191 patients enrolled in 50 randomized controlled trials. Am J Hematol 2004;75: 40-47. 21. Lee P, Chen W, Ng W, et al. Low-dose aspirin increases aspirin resistance in patients with coronary artery disease. Am J Med 2005; 118:723-727. Table 6  . . .
. . .  REVIEW Aspirin to Prevent Heart Attack and Stroke: Whats the Right Dose? James E. Dalen, MD, MPH Professor Emeritus, University of Arizona, Tucson ABSTRACT Despite hundreds of clinical trials, the appropriate dose of aspirin to prevent myocardial infarction . . .
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