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Abstract. . .  renoprotective effects of pioglitazone in genetically obese diabetic rats. Am J Physiol . 1997;272:E989E996. 9. Fullert S, Schneider F, Haak E, Rau H, Badenhoop K, Lubben G, Usadel KH, Konrad T. Effects of pioglitazone in nondiabetic patients with arterial hypertension : a double-blind, placebo-controlled study. J Clin Endocrinol Metab . 2002;87:55035506. 10. Nicholas SB, Kawano Y, Wakino S, Collins . . .
. . .  (top) and eNOS (bottom) in renal cortex and medulla in OP rats with or without pioglitazone treatment. Results represent mean SEM of 6 rats per group. Dobrian et al Pioglitazone Prevents Hypertension in Obesity 55 Page 9 Perspectives This study shows for the first time the in vivo regulation of PPAR expression and activity in . . .
. . .  Kamisaki Y. PPAR ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. Eur J Pharmacol . 2002;448: 231238. 56 Hypertension January 2004  . . .
. . .  hypertension . Hypertension . 2002;39:667672. 34. Shiojiri T, Wada K, Nakajima A, Katayama K, Shibuya A, Kudo C, Kadowaki T, Mayumi T, Yura Y, Kamisaki Y. PPAR ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. Eur J Pharmacol . 2002;448: 231238. 56 Hypertension January 2004  . . .
. . .  monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst. J Immunol . 2002;169: 26192626. 23. Garg R, Kumbkarni Y, Aljada A, Mohanty P, Ghanim H, Hamouda W, Dandona P. Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodila- tation in obese subjects. Hypertension . 2000;36:430435. 24. Dobrian AD, Davies . . .
. . .  Regulation of PPAR transcriptional activity in 3T3-L1 adipocytes. Biochem Biophys Res Commun . 2003;300:429436. 33. Makino A, Skelton MM, Zou AP, Roman RJ, Cowley AW Jr. Increased renal medullary oxidative stress produces hypertension . Hypertension . 2002;39:667672. 34. Shiojiri T, Wada K, Nakajima A, Katayama K, Shibuya A, Kudo C, Kadowaki T, Mayumi T, Yura Y, Kamisaki Y. PPAR ligands inhibit . . .
. . .  Regulation of PPAR transcriptional activity in 3T3-L1 adipocytes. Biochem Biophys Res Commun . 2003;300:429436. 33. Makino A, Skelton MM, Zou AP, Roman RJ, Cowley AW Jr. Increased renal medullary oxidative stress produces hypertension . Hypertension . 2002;39:667672. 34. Shiojiri T, Wada K, Nakajima A, Katayama K, Shibuya A, Kudo C, Kadowaki T, Mayumi T, Yura Y, Kamisaki Y. PPAR ligands inhibit  . . .
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