Abstract: . . .  The Second Australian National Blood Pressure Study Page 1 of 6 8/08/01 Background Outcome of treatment of hypertension Over the past 25 years studies of the drug treatment of mild-moderate hypertension have demonstrated that reduction of blood pressure is associated with reduction in the risk of  . . .
. . .  major influence on practice not only in Australia but worldwide, and as a result will refine protocols for the optimal management of hypertension . It will re-establish Australia as one of the major sites for the conduct of successful large outcome studies in hypertension . Having the study conducted in Australian general practices is also likely to produce a result which is much more influential to Australia practice than those from studies conducted in other countries.  . . .
. . .  The design of the ANBP2 study will reflect the real world of the treatment of mild-moderate hypertension in older subjects in Australia as it will be conducted during the routine management of subjects fulfilling Australian guidelines for treatment. The success of the previous Australian National Blood Pressure Study over a decade ago indicates that large outcome studies of this magnitude can be planned and executed in Australia. This study is aimed at producing a definitive . . .
. . .  Page 4 The Second Australian National Blood Pressure Study Page 4 of 6 8/08/01 GP Involvement This study is being undertaken in general practice because that is where the majority of hypertension is seen and managed. Indeed, because of the number of patients required to give statistically significant results it is the only place research of this nature can take place. This also has the benefit of providing results directly related . . .
. . .  Sweden (STOP- Hypertension II) and another is proposed in the United Kingdom. In addition, an outcome study in systolic hypertension in the elderly (Syst-Eur) is in progress using the calcium channel antagonist nitrendipine as its primary drug therapy. STOP- Hypertension II is in subjects 70-84 years of age with moderate-severe hypertension - the entry criterion is a supine blood pressure 180/105 mmHg. The United Kingdom study is examining a different group, namely age 50 . . .
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