Abstract: . . .  well understood. Geographic compari- sons of entire regions have indicated that death rates from ischemic heart disease tend to be higher in areas where magnesium concentra- tions in soil and water are low. Several actions of the magnesium ion could provide some cardioprotective effects. 95 Low concentrations of magnesium in laboratory animals seem to potentiate catecholamine- induced myocardial necrosis. 96 Early after the onset of myocardial ischemia, magnesium infusion might limit the progression of is- chemic to infarcted . . .
. . .  Collins, personal communication, 1997). This finding appears to be consistent with the results of the earlier short-term nitrate trials. Overall, the data do not support the routine use of nitrates for long Page 9 Chapter 3 / Effects of Medical Therapies on Acute Myocardial Infarction and Unstable Angina Pectoris 73 periods after acute MI. The subgroup analysis finding from the ISIS- 4 and GISSI-3 data of a significant 17% odds reduction in favor of nitrates during the first 24 hours after acute MI is . . .
. . .  personal communication, 1997). This finding appears to be consistent with the results of the earlier short-term nitrate trials. Overall, the data do not support the routine use of nitrates for long Page 9 Chapter 3 / Effects of Medical Therapies on Acute Myocardial Infarction and Unstable Angina Pectoris 73 periods after acute MI. The subgroup analysis finding from the ISIS- 4 and GISSI-3 data of a significant 17% odds reduction in favor of nitrates during the first 24 hours after acute MI is encouraging. . . .
. . .  patients. The most common side effect of nitrates is headache. Nausea and vomiting, which are usually self-limiting, occasionally occur. Para- doxical bradycardia and hypotension have been reported after sublin- gual or intravenous nitrate administration, usually in patients with acute MI or ischemia. 89 Reduced systemic oxygen saturation has been reported in patients with chronic obstructive lung disease after the use of nitrates. The reason for this complication is not clear, but it is believed due to the inappropriate reduction of right ventricular . . .
. . .  and water are low. Several actions of the magnesium ion could provide some cardioprotective effects. 95 Low concentrations of magnesium in laboratory animals seem to potentiate catecholamine- induced myocardial necrosis. 96 Early after the onset of myocardial ischemia, magnesium infusion might limit the progression of is- chemic to infarcted myocardium and reduce the risk of arrhythmias induced by increased conc . . .
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