Abstract: . . .  contractile muscle apparatus. It participates in the regulation of striated muscles con- traction. Three different molecules of troponin have to date been identified in man: troponin T, troponin I (pre- sent by various isoforms in the skeletal and heart mus- cle), and troponin C. Troponin T is not detectible in the blood of healthy subjects, but appears 2-8 hours after onset of myocardial tissue ischemia. About 6% of troponin T (TnT) is de- composed to cytosol, . . .
. . .  Cardiac troponins are used as highly sensitive and specific markers for detection of myocardial damage. Particularly useful is troponin T, which, as a protein of the contractile apparatus, is unique to the primary structure of cardiac muscle. At our Clinic, it is possible to determine the levels of troponin T, whilst detection of troponin I still remains impossible. Due to the develop- ment of ELISA immunoassay, a possible increase in the Page . . .
. . .  Ravkilde J, Heickendorff L. Appli- cability of cardiac troponin T and I for early risk stratification in unstable coronary artery disease. Circulation 1997; 96: 2578-2585. 14. Lindahl B, Venfe P, Wallentin L. Relation between troponin T and risk of subsequent cardiac events in unstable coronary artery disease. Circulation 1996; 93: 1651-1557. TROPONIN T U NESTABILNOJ ANGINI PEKTORIS Ivana Burazor, Mirko Burazor Klinika za kardiovaskularne bolesti, Klinicki . . .
. . .  to 18 mukaraca i 12 ena. Notirani su anamnesticki podaci o bolu i faktorima rizika, detaljno uraden laboratorijski pregled koji je obuhvatio i proveru vrednosti kardiospecificnih enzima. Troponin T odredivan je kvantitativno na aparatu Cardiac Reader na mestu uzimanja krvi, u Koronarnoj jedinici. Ispitanici su praceni kako tokom hospitalizacije tako i do kontrolnog pregleda uradenog nakon 6 nedelja u smislu pojave novog dogadaja. Troponin T bio je detektibilan u . . .
. . .  pa- tients, whilst all patients underwent cardiosurgical in- tervention for single or double by-pass. These patients, at the moment of hospitalization, also showed the pres- ence of troponin T. Of them, two did not have any changes on ECG, and none had elevated values of CK and CK MB. The results also suggest the sensitivity and specificity of the markers in APNS. Lindahl et al. (14), after treating 974 patients, con- clude that the increased TnT value . . .
. . .  effective means for diagnosis of patients with chest pain and suspected of having myocardial damage, as well as for prognosis of new events. All this has been confirmed by this study. Conclusion Troponin T in patients with APNS showed a high specificity. It helped to distinguish a group of patients at high risk in the follow-up period of six weeks. This group can be labeled as Troponin T-positive angina and is marked by an elevated level of damage . . .
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