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Abstract: . . . an outpatient basis if the evaluation can be completed within 72 hours after discharge. 47 High-risk patients Figure 4. Incidence of the Failure of Medical Therapy According to the Number of Risk Factors Present on Admission. In patients treated conservatively, the incidence of the failure of medical therapy, which led to prompt coronary angiography and revascularization, increased substantially as the number of base-line risk factors increased. These factors included the pres- ence of ST-segment depression on admission, a history of an- gina, older age, a family history of coronary artery disease, and the use of aspirin or heparin. P<0.001 for the comparison among the groups. Adapted from Stone et al., 129 with the permission of the publisher. 0 100 0 6 20 40 60 80 1 2 3 P<0.001 4 5 No. of . . . . . . 7. Ambrose JA, Winters SL, Arora RR, et al. Angiographic evolution of coronary artery morphology in unstable angina . J Am Coll Cardiol 1986; 7:472-8. 8. Ambrose JA, Tannenbaum MA, Alexopoulos D, et al. Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988;12:56-62. 9. Alison HW, Russell RO Jr, Mantle JA, Kouchoukos NT, Moraski RE, Rackley CE. Coronary anatomy and arteriography in patients with unstable angina pectoris . Am J Cardiol 1978;41:204-9. 10. Fuster V, Frye RL, Connolly DC, Danielson MA, Elveback LR, Kurland LT. Arteriographic patterns early in the onset of coronary syn- dromes. Br Heart J 1975;37:1250-5. 11. Ambrose JA, Winters SL, Stern A, et al. Angiographic morphology and the pathogenesis of unstable angina pectoris . J Am Coll Cardiol 1985; 5:609-16. 12. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J. . . . . . . Lecture: mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 1994;90:2126-46. [Erratum, Circulation 1995;91:256.] 15. Throux P, Fuster V. Acute coronary syndromes: unstable angina and non-Q-wave myocardial infarction. Circulation 1998;97:1195-206. 16. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT. Distribu- tion of circumferential stress in ruptured and stable atherosclerotic lesions: a structural analysis with histopathological correlation. Circulation 1993; 87:1179-87. 17. Henney AM, Wakeley PR, Davies MJ, et al. Local . . . --3000,3,500,2855,64628
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