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Abstract: . . . ongoing angina (>20 minutes) No ST-segment deviation No cardiac enzymes detected Aspirin (perhaps with glycoprotein IIb/IIIa inhibitor) Heparin (unfractionated heparin or low-molecular-weight heparin) Beta-blockers Nitrates Calcium-channel blocker (possibly) Recurrent ischemia? Risk-stratifying tests (exercise-tolerance test, perfusion scintigraphy) Medical therapy (risk-stratifying tests possibly performed on an outpatient . . . . . . angina Angina after myocardial infarction Prior use of intensive anti-ischemic regimen Older age Dynamic ST-segment deviation Cardiac enzymes detected Hemodynamic instability Initial Medical Therapy Hospital Course Strategy Page 12 112 January 13, 2000 The New England Journal of Medicine blockade with abciximab: one-year outcome in the EPILOG trial. Circula- . . . . . . heparin) Beta-blockers Nitrates Calcium-channel blocker (possibly) Recurrent ischemia? Risk-stratifying tests (exercise-tolerance test, perfusion scintigraphy) Medical therapy (risk-stratifying tests possibly performed on an outpatient basis) Medical therapy Negative results Positive results Coronary angiography and revascularization Expedited invasive strategy Angina at rest or prolonged . . . . . . Fuster V. Acute coronary syndromes: unstable angina and non-Q-wave myocardial infarction. Circulation 1998;97:1195-206. 16. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT. Distribu- tion of circumferential stress in ruptured and stable atherosclerotic lesions: a structural analysis with histopathological correlation. Circulation 1993; 87:1179-87. 17. Henney AM, Wakeley PR, Davies MJ, et al. Local . . . . . . Memorial Lecture: mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation 1994;90:2126-46. [Erratum, Circulation 1995;91:256.] 15. Throux P, Fuster V. Acute coronary syndromes: unstable angina and non-Q-wave myocardial infarction. Circulation 1998;97:1195-206. 16. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT. Distribu- tion of circumferential stress in ruptured and stable atherosclerotic lesions: a structural . . . . . . Elveback LR, Kurland LT. Arteriographic patterns early in the onset of coronary syn- dromes. Br Heart J 1975;37:1250-5. 11. Ambrose JA, Winters SL, Stern A, et al. Angiographic morphology and the pathogenesis of unstable angina pectoris . J Am Coll Cardiol 1985; 5:609-16. 12. Davies MJ, Richardson PD, Woolf N, Katz DR, Mann J. Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content. . . . --3000,6,250,3385,64628
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