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Abstract: . . . dinitrate: rate of development and reversal. Circulation 1983;68:1074-80. 93. Lange RL, Reid MS, Tresch DD, Keelan MH, Bernhard VM, Coolidge G. Nonatheromatous ischemic heart disease following withdraw- al from chronic industrial nitroglycerin exposure. Circulation 1972;46: 666-78. 94. Morton WE. Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension. J Occup Med 1977;19:197-200. 95. Waters DD, Juneau M, Gossard D, Choquette G, Brien M. Limited usefulness of intermittent nitroglycerin patches in stable angina . J Am Coll Cardiol 1989;13:421-5. 96. Olsson G, Allgen J, Amtorp O, Nyberg G, Parker JO. Absence of pre- dose . . . . . . Nitroglycerin Headache, postural hypoten- sion, syncope, nausea, skin erythema and inflammation at site of patch application Initiate treatment with small doses and increase as necessary; vary ap- plication site Figure 3. Diagram of the Treatment of Stable Angina with Antianginal Drugs. This scheme assumes that management decisions concerning possible revascular- ization have been made by using standard clinical approaches. Symptoms of Stable Angina Yes No Inadequate control of symptoms Symptoms during nitrate-free period Sublingual nitroglycerin Treatment of attacks Prophylactic therapy Long-acting nitrates . . . . . . industrial nitroglycerin exposure. Circulation 1972;46: 666-78. 94. Morton WE. Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension. J Occup Med 1977;19:197-200. 95. Waters DD, Juneau M, Gossard D, Choquette G, Brien M. Limited usefulness of intermittent nitroglycerin patches in stable angina . J Am Coll Cardiol 1989;13:421-5. 96. Olsson G, Allgen J, Amtorp O, Nyberg G, Parker JO. Absence of pre- dose rebound phenomena with once daily 5-ISMN in a controlled-release formulation. Eur Heart J 1992;13:814-7. 97. Mnzel T, Bassenge E. Long-term angiotensin-converting enzyme in- hibition with high-dose enalapril retards . . . . . . industrial nitroglycerin exposure. Circulation 1972;46: 666-78. 94. Morton WE. Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension. J Occup Med 1977;19:197-200. 95. Waters DD, Juneau M, Gossard D, Choquette G, Brien M. Limited usefulness of intermittent nitroglycerin patches in stable angina . J Am Coll Cardiol 1989;13:421-5. 96. Olsson G, Allgen J, Amtorp O, Nyberg G, Parker JO. Absence of pre- dose rebound phenomena with once daily 5-ISMN in a controlled-release formulation. Eur Heart J 1992;13:814-7. 97. Mnzel T, Bassenge E. Long-term angiotensin-converting enzyme in- hibition with high-dose enalapril retards nitrate . . . --3000,4,375,3303,64612
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