Abstract: . . .  frequency of genetic thrombophilia in women with complications of pregnancy. N Eng J Med 1999;340(1):9-13. Page 22 22 Table 1: Distribution of cases and controls according to demographic and lifestyle characteristics and family history of thrombosis Controls (n=76) Cases (n=41) Characteristic Mean Mean Age at Index Pregnancy 30 28 Gravidity 3.1 2.8 Parity 2.4 2.1 No. % No. % Race Black 27  . . .
. . .  Hematology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey Corresponding Author: Anne Dilley, Ph.D., Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop E-64, Atlanta, Georgia 30333. Telephone 404-371-5262 Running Head: Thrombosis in Pregnancy: Genetic Factors Page 2 2 CONDENSATION Factor V Leiden, the prothrombin 20210 G to A variant, and a deletion polymorphism in the angiotensin converting enzyme gene increase the risk of thrombosis during pregnancy.  . . .
. . .  control missing ACE gene result Page 24 24 Table 3: Distribution of Cases and Controls and Odds Ratio According to the Total Number of Allelic Mutations in the Factor V, Prothrombin, and ACE Genes Number of Allelic Mutations Among the Three Genes Cases Controls Odds Ratio (95% CI) 0 3 14 1.0 1 14 40 1.6 (0.4 - 7.7) 2 16 19 3.6 (0.9 - 18.6) 3 + 6 1 17 (1.7 - 491) Total 39 74  . . .
. . .  mutation in an obstetric population and its relationship to deep vein thrombosis . Am J Obstet Gynecol 1997;176(4):883-86. 7. Grandone E, Margaglione M, Colaizzo D, DAndrea G, Cappucci G, Brancaccio V, et al. Gene susceptibility to pregnancy-related venous thromboembolism: Roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations. Am J Obstet Gynecol 1998;179(5):1324-28. 8. Poort SR, Rosendaak FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'- untranslated region of the prothrombin . . .
. . .  Controls Odds Ratio (95% CI) 0 3 14 1.0 1 14 40 1.6 (0.4 - 7.7) 2 16 19 3.6 (0.9 - 18.6) 3 + 6 1 17 (1.7 - 491) Total 39 74 Odds Ratio increases by a factor of 2.6 (1.5, 4.5) 95% for each addition of a mutant allele  . . .
--3000,5,300,3155,39607