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Abstract: . . . in 14 other pregnancies (antepartum and puerperium) Pregnancy related VTE and CVST occurs most frequently during the Puerperium - recommend post partum anticoagulation Mehraein study: Unable to draw conclusion re need for prophylactic low dose anticoagulation ante partum Evidence of a very low risk of recurrent VTE for women with previous extracerebral venous thrombotic events if no thrombophila present or if the previous VTE was associated with a temporary RF Risk of recurrence increased if thrombophilia present or prior event was idiopathic (Brill-Edwards NEJM 2000;343:1439-44) Decision for prophylactic anticoagulation in women without thrombophilia or persisting prothrombotic RF may also be based on interval between previous CVST and . . . . . . unilateral hemispheric symptoms (ie: hemiparesis or aphasia) followed by symptoms from the other hemisphere within days (cortical lesions on both sides of the superior sagittal sinus) Seizures 40% (much more common than in other stroke types) Thrombosis of deep vein system (straight sinus and its branches) centrally located, often bilateral thalamic lesions behavioural symptoms delirium, amnesia, mutism Compression of diencephalon or brainstem comatose or die from cerebral herniation 3. Cavernous Sinus Thrombosis (3%) chemosis, proptosis, . . . . . . with arterial stroke proportion of permanently dependent patient ranges between 1-2/3 of survivors Prognosis ISCVT Important prognostic factors for death or dependence Coma (GCS < 9) Cerebral Haemorrhage Malignancy Additional RF identified in ISCVT Male sex Age > 37 years Mental status disorder Thrombosis of deep cerebral venous system straight sinus CNS infection Pregnancy and Risk of recurrence History of CVST does not preclude a subsequent pregnancy Mehraein, JNNP 2003;74:814-816 39 patients of childbearing age 22 pregnancies and 19 births in 14 patients no recurrence of CVST and no extracerebral thrombotic complications . . . --2572,3,429,2844,12860
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