Abstract: . . .  VAT in ESRD and other chronic conditions [12 -14] . Boushey, Beresford, Omenn, and Motulsky (1995) Page 2 identified hyperhomocysteinemia as an independent risk factor for VAT. Investigators have found significantly higher homocysteine levels in patients with recurrent VAT compared with one or more episodes of thrombosis [14] . Total homocysteine levels were higher among those with a history of previous VAT when compared to those who did not have a history of such events. Initial prospective evidence supports an independent association between tHcy levels and the development of hemodialysis access thrombosis [4] . In one study it was demonstrated that a 1 u M/L increase in plasma tHcy was associated with a 4% increase in the risk for access thrombosis [4] . Mallamaci et al. (2002) also reported a strong association between . . .
. . .  Press). 18. Kes, P. Hyperhomocysteinemia in end-stage renal failure. Acta Med. Croat. 2000; 53(4-5): 175-181. 19. McCully, KS. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969; 56: 111-118. 20. Qur I; Perneger TV; Zittoun J; Bellet H; Gris JC; Daurs JP; Schved JF; Mercier E; Laroche JP; Dauzat M; Bounameaux H; Janbon C; de Moerloose P. Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study. Lancet, 2002 Mar 2; 359 (9308): 747 -52. 21. Ifudu, O, Macey, LJ, Homel, P, Hyppolite, JC, Hong, J, Sumrani, N, Distant, D, Sonner, BG, Friedman, EA. Determinants of type of initial hemodialysis vascular access. Am J Nephrol, 1997 17(5): 425-427. Your questions, contributions and commentaries will be answered by the authors in the Clinical Cardiology list. Please fill in the form and press the "Send" button.  . . .
. . .  Stampfer, MJ. Interrelation of hyperhomocysteinemia, factor V Leiden, and risk of future venous thromboembolism. Circulation. 1997; 95: 1777-1782. 16. Sirrs, S, Duncan, L, Ognjenka, D, Nussbaumer, G, Ganz, G, Frohlich, J, Levin, A. Homocyst(e)ine and vascular access complications in haemodialysis patients: insights into a complex metabolic relationship. Nephrol Dial Transplant 1999; 14: 738- 743. 17. Bowden, RG, Wyatt, F, Wilson, R. Homocysteine and Vascular Access Thrombosis in End-Stage Renal Disease Patients: A Retrospective Study. J Nephrol, 2003 (In Press). 18. Kes, P. Hyperhomocysteinemia in end-stage renal failure. Acta Med. Croat. 2000; 53(4-5): 175-181. 19. McCully, KS. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969; 56: 111-118. 20. Qur I; Perneger TV; Zittoun J; Bellet H; Gris JC; Daurs JP; Schved JF; Mercier E; Laroche JP; Dauzat M; Bounameaux H; . . .
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