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Abstract: . . . Antiphospholipid thrombosis : clinical course after the first thrombotic event in 70 patients. Ann Intern Med 1992; 117: 303-308. 10. Palareti G, Leali N, Coccheri S, et al. Bleeding complications of oral anticoagu- lant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Lancet 1996; 348: 423-428. 11. Crowther MA, Ginsberg JS, Julian J, et al. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphos- pholipid antibody syndrome. N Engl J Med 2003; 349: 1133-1138. ? Graded physical exercise is no panacea, but is beneficial M UCH REMAINS UNKNOWN ABOUT the enigmatic clinical disorder chronic fatigue syndrome (CFS). Apart from clear evidence implicating certain infections as a trigger, and reproducible evidence of increased rates of comorbid depression, the aetiology . . . . . . daytime naps. Accord- ingly, the CBT approach generally seeks to alter these cognitive attributions and modify the associated behavioural patterns. Having established CBT as a beneficial treatment approach, subsequent studies have sought to identify the active components of the CBT package. In this regard, graded physical exercise therapy has been found in several studies to be significantly better than comparators such as relaxation therapy, notably in reducing symptom severity and gaining improved function. 6-8 In particular, Fulcher and MJA Vol 180 3 May 2004 437 . . . . . . associated behavioural patterns. Having established CBT as a beneficial treatment approach, subsequent studies have sought to identify the active components of the CBT package. In this regard, graded physical exercise therapy has been found in several studies to be significantly better than comparators such as relaxation therapy, notably in reducing symptom severity and gaining improved function. 6-8 In particular, Fulcher and MJA Vol 180 3 May 2004 437 . . . --2880,3,480,2417,14401
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