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Abstract: . . . nocturnal haemoglobinuria. Br J Haematol 1996, 92: 707-10. 5. von Stuckrad-Barre S, Berkefeld J, Steckel D, Sitzer M: Cerebral arterial thrombosis in paroxysmal nocturnal haemoglobinuria. J Neurol 2003, 250: 756-7. 6. Melandri F, Gazzotti G, Fontana P, Accietto C: [Recurrent acute myocardial infarction in a patient with paroxysmal nocturnal haemoglobinuria]. Ital Heart J 2001, Suppl 2: 792-4 Italian. 7. Van Vleymen B, Dhaene I, Van Hoof A, Pattyn G: Cerebral venous thrombosis in paroxysmal nocturnal haemoglobinuria. Acta Neurol Belg 1987, 87: 80-7. 8. Alfaro A: Cerebral venous thrombosis in paroxysmal noctur- nal haemoglobinuria. J Neurol Neurosurg Psychiatry 1992, 55: 412. 9. Schwammenthal Y, Tanne D: Homocysteine, B-vitamin supple- mentation, and stroke prevention: from observational to interventional trials. Lancet Neurol 2004, 3: 493-5. 10. Hankey GJ: Homocysteine-lowering therapy did not prevent stroke recurrence. ACP J Club 2004, 141: 21. 11. Al-Delaimy WK, Rexrode KM, Hu FB, Albert CM, Stampfer MJ, Wil- lett WC, Manson JE: Folate intake and risk of stroke among women. Stroke 2004, 35: 1259-63. . . . . . . concentration (g/dl) 32 3236 white blood cells (cells/mm 3 ) 4.040 4.800 10.800 Platelets (cells/mm 3 ) 93.000 130.000 400.000 Reticulocytes (%) 5,4 <2 haemoblobinuria traces absent Hemosiderinuria present absent Coombs'test negative negative cold agglutinins negative negative Peripheral blood smear Normal Bone marrow biopsy slight hyperplasia of erythrocytic cell line Immunophenotypic profile of peripheral blood cells 15% of deficient CD59 erythrocytes Page 4 Thrombosis Journal 2004, 2 :10 http://www.thrombosisjournal.com/content/2/1/10 Page 4 of 4 (page number not for citation purposes) therapy with warfarin according with INR value in range of 22,5. Moreover she was treated with B12 vitamin and folate supplementation. Discussion The association between haematological diseases and thromboembolic events is well established. In particular high thrombotic risk is recognized in patients with essen- tial thrombocythemia, polycythemia vera, PNH and drepanocytosis [ 3 ]. PNH is associated to venous thrombo- sis in approximately one third of cases. The most fre- quently reported locations are unusual such as mesenteric vessels, sagittal veins, inferior vena cava and . . . --3000,2,750,3045,17843
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