Abstract: . . .  embolism who have to undergo urgent surgery, who have severe thrombocytopenia, or have active and potentially life-threatening bleeding. In all cases, anticoagulant therapy is restarted when normal hemosta- sis is achieved. We do not routinely insert filters in patients with reversible, controllable bleeding or brain tumors. In the former setting, we reduce the dose or withhold anticoagulant therapy temporarily and reintroduce anticoagulants when hemostasis is  . . .
. . .  recurrent pregnancy loss. This latter group requires special consideration because anticoagu- lant and antiplatelet therapy may improve future pregnancy out- comes if underlying thrombophilia is documented. 42 Our standard screening panel includes functional assays for antithrombin and protein C, free protein S level, activated protein C resistance assay with DNA testing for factor V Leiden if positive, molecular assay for prothrombin G20210A mutation, a . . .
. . .  prophylaxis against ve- nous thromboembolism after total knee replacement. for the AstraZenca Arthroplasty Study Group. A phase 2 dose-finding study. Arch Intern Med. 2001;161:2215-2221. 48. Goldhaber SZ. Thrombolytic therapy for venous thromboembolism. Baillieres Clin Haematol. 1990;3:693-704. 49. Sasahara AA, St.Martin CC, Henkin J, Barker WM. Approach to the patient with venous throm- boembolism. Treatment with thrombolytic agents. Hematol . . .
. . .  inferior vena cava filter use among patients with venous thromboembolism. Arch Intern Med. 2000;160: 2033-2041. 55. Costedoat-Chalumeau N, Amoura Z, Aymard G, et al. Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone. Ann Intern Med. 2000;132:631-635. 3110 HIRSH and LEE BLOOD, 1 MAY 2002 VOLUME 99, NUMBER 9  . . .
. . .  filters: a comprehensive review. Blood. 2000;95:3669-3677. 53. Decousus H, Leizorovicz A, Parent F, et al. A clini- cal trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis . Prevention du Risque dEmbolie Pulmonaire par Interruption Cave Study Group. N Engl J Med. 1998;338:409-415. 54. White RH, Zhou H, Kim J, Romano PS. A popula- tion-based study of the effectiveness of inferior vena . . .
. . .  19. Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR. The management of throm- bosis in the antiphospholipid-antibody syndrome. N Engl J Med. 1995;332:993-997. 20. Prandoni P, Cogo A, Bernardi E, et al. A simple ultrasound approach for detection of recurrent proximal-vein thrombosis . Circulation. 1993;88: 1730-1735. 21. Gould MK, Dembitzer AD, Doyle RL, Hastie TJ, Garber AM. Low-molecular-weight heparins com- pared with unfractionated . . .
--3000,6,250,3336,64084