Abstract: . . .  Further, there is no agreement on whether systemic or catheter-directed thrombolysis is the preferred method of delivery. A recent randomized controlled trial comparing UFH alone with 4 regimens of systemic or regional thrombolysis showed greater venographic improvement at 12 months with systemic thrombo- lytic therapy, but at a cost of substantially higher rates of major bleeding and pulmonary embolism compared with UFH. 51 There- fore, even . . .
. . .  overall mortality after 2 years. Similar results are reported by a population-based analysis in more than 3600 patients in whom a filter was inserted for DVT. 54 At our hospitals, we insert filters in patients with a newly diagnosed proximal DVT or pulmonary embolism who have to undergo urgent surgery, who have severe thrombocytopenia, or have active and potentially life-threatening bleeding. In all cases, anticoagulant therapy is restarted when normal hemosta- . . .
. . .  Intern Med. 2000;160: 2033-2041. 55. Costedoat-Chalumeau N, Amoura Z, Aymard G, et al. Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone. Ann Intern Med. 2000;132:631-635. 3110 HIRSH and LEE BLOOD, 1 MAY 2002 VOLUME 99, NUMBER 9  . . .
. . .  complications of throm- bolytic therapy in the treatment of myocardial in- farction and venous thromboembolism. Chest. 1995;108:291S-301S. 51. Schweizer J, Kirch W, Koch R, et al. Short-and long-term results after thrombolytic treatment of deep venous thrombosis . J Am Coll Cardiol. 2000;36:1336-1343. 52. Streiff MB. Vena caval filters: a comprehensive review. Blood. 2000;95:3669-3677. 53. Decousus H, Leizorovicz A, Parent F, et al. A clini- cal . . .
. . .  Vena caval filters: a comprehensive review. Blood. 2000;95:3669-3677. 53. Decousus H, Leizorovicz A, Parent F, et al. A clini- cal trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis . Prevention du Risque dEmbolie Pulmonaire par Interruption Cave Study Group. N Engl J Med. 1998;338:409-415. 54. White RH, Zhou H, Kim J, Romano PS. A popula- tion-based study of the effectiveness of inferior . . .
. . .  caval filters: a comprehensive review. Blood. 2000;95:3669-3677. 53. Decousus H, Leizorovicz A, Parent F, et al. A clini- cal trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis . Prevention du Risque dEmbolie Pulmonaire par Interruption Cave Study Group. N Engl J Med. 1998;338:409-415. 54. White RH, Zhou H, Kim J, Romano PS. A popula- tion-based study of the effectiveness of inferior  . . .
--3000,6,250,3222,64084