Abstract: . . .  Coronary Artery Disease n Dyslipidemia n Disorders of lipoprotein metabolism, may be manifested by > total serum cholesterol > LDL and triglycerides < HDL cholesterol concentration n Causal relationship between > cholesterol levels and CHD. Cholesterol lowering Rx reduces lipid content of atherosclerotic plaque (e.g. Simvastatin) 14 Coronary Artery Disease n Hyperhomocysteine n Due to a genetic lack of the enzyme that breaks down homocysteine n And/or a nutritional lack of folate, cobalamin, or pyridoxine < levels of folic acid, . . .
. . .  risk factors Venous stasis: immobility, age, left heart failure Vessel damage: trauma, IV medications > Coagulation: pregnancy, oral contraception, some cancers, coagulation disorders n Prevention: ambulation following surgery! 18 Cardiac Inflammation n Myocarditis: forms scar tissue n inflammation & injury of myocardium without ischemia n caused by an infection with virus or bacterial protein that triggers an autoimmune attack on myocardial cells n CMV, HIV, Hep B, coxsackievirus n TB, B-hemolytic strep, slamonella, lyme disease n fungi: candidiasis, . . .
. . .  Scleroderma, pulmonary hypertension, malignancy n Raynaud Disease n Primary vasospastic disorder n the digit turns white, blue, red pain, numbness & cold sensation may be present 17 DVT n Deep Vein Thrombosis n Asymptomatic, however associated with risk factors Venous stasis: immobility, age, left heart failure Vessel damage: trauma, IV medications > Coagulation: pregnancy, oral contraception, some cancers, coagulation disorders n Prevention: ambulation following surgery! 18 Cardiac Inflammation n Myocarditis: forms scar tissue  . . .
. . .  and Stroke Statistical Update. Dallas, Tex.: American Heart Association; 2001. n Bullock, B. A. & Reet, L. H. (2000). Focus on Pathophysiology. Philadelphia: Lippincott. n Corwin, E.J.(2000).Handbook of pathophysiology. Baltimore: Lippincott. n Hansen, M. (1998). Pathophysiology: Foundations of disease and clinical intervention. Philadelphia: Saunders. n Hartshorn, J. C., Sole, M. L., & Lamborn, M. L. (1997).Introduction to critical care nursing.Philadelphia: Saunders. n Huether, S. E., & McCance, K. L. (2002). Pathophysiology. St. Louis: Mosby. n http://www.heartsite.com n Illustrations . . .
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