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Abstract: . . . ( r 0.48; p 0.009) (Fig 1). The volume of CA1 was correlated with the volume of CA2 ( r 0.59; p 0.009) (Fig 1). The coefficient of error for these estimates averaged 0.10 0.02 for number of neurons in CA1 and 0.12 0.04 for number of neurons in CA2. Premortem Magnetic Resonance Imaging Hippocampal Volume Correlates with Neuron Number Hippocampal volumes were determined from premor- tem MRIs (Fig 2). MRI hippocampal volumes were highly correlated with the number of neurons in CA1 ( r 0.72; p 0.0004) and volume of CA1 ( r 0.54; p 0.02) but not CA2. In addition, MRI hippocam- pal volumes were highly correlated with . . . . . . 27. Lye TC, Piguet O, Grayson DA, et al. Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study. J Neurol Neurosurg Psychiatry 2004;75:548554. 28. Petersen RC, Jack CR Jr, Xu YC, et al. Memory and MRI- based hippocampal volumes in aging and AD. Neurology 2002; 54:581587. Zarow et al: Hippocampal Neurons in AD and IVD 903 . . . . . . Piguet O, Grayson DA, et al. Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study. J Neurol Neurosurg Psychiatry 2004;75:548554. 28. Petersen RC, Jack CR Jr, Xu YC, et al. Memory and MRI- based hippocampal volumes in aging and AD. Neurology 2002; 54:581587. Zarow et al: Hippocampal Neurons in AD and IVD 903 . . . . . . Sabbagh MN, Bondi MW, et al. Hippocampal sclerosis contributes to dementia in the elderly. Neurology 1997;48:154160. 25. Crystal HA, Dickson DW, Sliwinski MJ, et al. Pathological markers associated with normal aging and dementia in the el- derly. Ann Neurol 1993;34:566573. 26. Harding AJ, Halliday GM, Kril JJ. Variation in hippocampal neuron number with age and brain volume. Cereb Cortex 1998;8:710718. 27. Lye TC, Piguet O, Grayson DA, et al. Hippocampal size and memory function in the ninth and tenth decades of life: the Sydney Older Persons Study. J Neurol Neurosurg Psychiatry 2004;75:548554. 28. Petersen RC, Jack CR Jr, Xu YC, et al. Memory and MRI- based hippocampal volumes . . . --3000,4,375,2629,36424
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