Abstract: . . .  laboratories: Assess nephropathy, retinopathy, neuropathy, uropathy 5. Ship additional mice to AMDCC core laboratories for functional studies (neuropathy, uropathy, cardiomyopathy) Page 17 Platform Models: C57BL/6J LDLR-/- Mouse Hyperglycemia: Pdx1+/-; Ins2 Akita/+ Insulin Resistance: IRS1-/-; Akt2-/-* Combination: Ob/Ob Sensitizer: HuARTg**; SOD2+/-** Founders: * 10% outbred; ** 20% outbred and currently backcrossing  . . .
. . .  distribution to AMDCC core laboratories: Assess nephropathy, retinopathy, neuropathy, uropathy 5. Ship additional mice to AMDCC core laboratories for functional studies (neuropathy, uropathy, cardiomyopathy) Page 17 Platform Models: C57BL/6J LDLR-/- Mouse Hyperglycemia: Pdx1+/-; Ins2 Akita/+ Insulin Resistance: IRS1-/-; Akt2-/-* Combination: Ob/Ob Sensitizer: HuARTg**; SOD2+/-** Founders: * 10% outbred; ** 20% outbred and currently backcrossing . . .
. . .  lesion(%) 8.2 1.0 7.9 0.9 8.9 1.0 16.1 1.9 # Aortic arch (%) 3.3 0.7 4.5 1.2 15.0 2.8 30.7 4.2 # Mean SEM. *P<0.05 vs. non-diabetics, #P<0.05 vs. non-transgenic diabetics Page 16 C57BL/6J LDLR-/- & LDLR+/- HuARTg mice show STZ induced enhancement of en face lesion area Plan: 1. STZ-induced hyperglycemia studies: optimize diet and duration and extend analysis . . .
. . .  Mouse Models of Diabetic Macrovascular Disease RU/Columbia/NYU Group 1. Create new mouse models of diabetes Markus Stoffel-RU 2. Create mouse models of diabetic dyslipidemia Ira Goldberg-Columbia 3. Effect of diabetes on atherosclerosis progression Jan Breslow-RU . . .
. . .  Mouse Models of Diabetic Macrovascular Disease RU/Columbia/NYU Group 1. Create new mouse models of diabetes Markus Stoffel-RU 2. Create mouse models of diabetic dyslipidemia Ira Goldberg-Columbia 3. Effect of diabetes on atherosclerosis progression Jan Breslow-RU  . . .
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