Abstract: . . .  mouse plaques occurs during regression and this process requires CCR7 Page 48 AMDCC, Baltimore, March 21-22, 2006 Hayes Dansky Page 49 AMDCC, Baltimore, March 21-22, 2006 Major Goal: Create Mouse Models In which Diabetes Worsens Atherosclerosis Hypotheses 1. Mice do not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis . . .
. . .  plaques occurs during regression and this process requires CCR7 Page 48 AMDCC, Baltimore, March 21-22, 2006 Hayes Dansky Page 49 AMDCC, Baltimore, March 21-22, 2006 Major Goal: Create Mouse Models In which Diabetes Worsens Atherosclerosis Hypotheses 1. Mice do not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis . . .
. . .  1. Mice do not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis in diabetic mice is due to a defect in lesion regression. 3. Diabetic macrovascular disease is due to hyperinsulinemia, insulin resistance. Page 50 AMDCC, Baltimore, March 21-22, 2006 Effects of HF diets on glucose and atherosclerosis Glucose 129 7 169 5 122 9  . . .
. . .  Mice do not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis in diabetic mice is due to a defect in lesion regression. 3. Diabetic macrovascular disease is due to hyperinsulinemia, insulin resistance. Page 50 AMDCC, Baltimore, March 21-22, 2006 Effects of HF diets on glucose and atherosclerosis Glucose 129 7 169 5 122 9 182 9  . . .
. . .  not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis in diabetic mice is due to a defect in lesion regression. 3. Diabetic macrovascular disease is due to hyperinsulinemia, insulin resistance. Page 50 AMDCC, Baltimore, March 21-22, 2006 Effects of HF diets on glucose and atherosclerosis Glucose 129 7 169 5 122 9 182 9 Cholesterol . . .
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