Abstract: . . .  Bethesda, October 17, 2005 Plaque Instability? Movats Pentachrome CD31 (endothelial cells) Movats Pentachrome Page 35 AMDCC, Bethesda, October 17, 2005 Platform Models: C57BL/6J LDLR-/- Mouse Hyperglycemia: Pdx1+/-; Ins2 Akita/+ Insulin Resistance: IRS1-/-; Akt2-/-* Combination: Ob/Ob Sensitizer: HuARTg**; SOD2+/-** hAR inhibitors * currently 1-2% outbred  . . .
. . .  Page 34 AMDCC, Bethesda, October 17, 2005 Plaque Instability? Movats Pentachrome CD31 (endothelial cells) Movats Pentachrome Page 35 AMDCC, Bethesda, October 17, 2005 Platform Models: C57BL/6J LDLR-/- Mouse Hyperglycemia: Pdx1+/-; Ins2 Akita/+ Insulin Resistance: IRS1-/-; Akt2-/-* Combination: Ob/Ob Sensitizer: HuARTg**; SOD2+/-** hAR inhibitors * currently 1-2% outbred  . . .
. . .  L esi o n A r ea ( x10 4 um 2 ) Page 32 AMDCC, Bethesda, October 17, 2005 In summary, Ob/Ob makes Ldlr -/- females more insulin resistant and diabetic than males, but results in less increase in the cholesterol to HDL ratio and athero- sclerosis than in males. These data suggest that glucose levels have little effect on atherosclerosis, whereas the major influence on atherosclerosis appears . . .
. . .  Mice do not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis in diabetic mice is due to a defect in lesion regression. 3. Diabetic macrovascular disease is due to hyperinsulinemia, insulin resistance. Studies of high fat feeding and ob/ob Page 25 AMDCC, Bethesda, October 17, 2005 Effects of HF diets on glucose and atherosclerosis Glucose 129  . . .
. . .  not develop diabetes-induced acceleration of macrovascular disease because they are genetically deficient in a glucose sensitive gene. 2. Increased atherosclerosis in diabetic mice is due to a defect in lesion regression. 3. Diabetic macrovascular disease is due to hyperinsulinemia, insulin resistance. Studies of high fat feeding and ob/ob Page 25 AMDCC, Bethesda, October 17, 2005 Effects of HF diets on glucose and atherosclerosis Glucose 129 7 169 . . .
--3000,5,300,3288,15406