Abstract: . . .  Expression Restorative Not Pharmacological Heart mRNA Northern Blot Mouse LDLR-/-HuARTg Mouse LDLR-/- Human Human AR Mouse AR GAPDH Page 8 Study Design (in progress) LDLR-/- mice X HuARTg mice LDLR+/-HuARTg vs. LDLR+/- Con . . .
. . .  Major Goal: Create Mouse Model Diabetes Worsens Atherosclerosis Strategy: 1. Create mice with diabetic dyslipidemia 2. Cross with models of hyperglycemia, insulin resistance or both 3. Assess effects on atherosclerosis progression, regression and response to arterial injury  . . .
. . .  4410 p=0.8000 Triglycerides mg/dl 10936 7317 p=0.0020 Page 16 C57BL/6J LDLR-/- HuARTg mice made diabetic with STZ have enhanced en face lesion area Plan: 1. STZ-induced hyperglycemia studies: optimize diet and duration and extend analysis . . .
. . .  Mouse Models of Diabetic Macrovascular Disease RU/Columbia/NYU Group 1. Create new mouse models of diabetes Markus Stoffel-RU 2. Create mouse models of diabetic  . . .
. . .  Mouse Models of Diabetic Macrovascular Disease RU/Columbia/NYU Group 1. Create new mouse models of diabetes Markus Stoffel-RU 2. Create mouse models of diabetic dyslipidemia . . .
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