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Abstract: . . . Circulation 96 , 19651991 20 Behm, D. J., Herold, C. L., Ohlstein, E. H., Knight, S. D., Dhanak, D. and Douglas, S. A. (2002) Pharmacological characterization of SB-710411 (Cpa- c [ D -Cys-Pal- D -Trp- Lys-Val-Cys]-Cpa-amide), a novel peptidic urotensin-II receptor antagonist. Br. J. Pharmacol. 137 , 449458 # 2003 The Biochemical Society and the Medical Research Society . . . . . . Pharmacol. 137 , 579588 4 Hillier, C., Berry, C., Petrie, M. C. et al. (2001) Effects of urotensin II in human arteries and veins of varying caliber. Circulation 103 , 13781381 5 Maguire, J. J., Kuc, R. E. and Davenport, A. P. (2000) Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1. Br. J. Pharmacol. 131 , 441446 6 Stirrat, A., Gallagher, M., Douglas, S. A. et al. (2001) Potent vasodilator responses to human urotensin-II in human pulmonary and . . . . . . Hormone Res. 41 , 533552 2 Ames, R. S., Sarau, H. M., Chambers, J. K. et al. (1999) Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature (London) 401 , 282286 3 Maguire, J. J. and Davenport, A. P. (2002) Is urotensin-II the new endothelin? Br. J. Pharmacol. 137 , 579588 4 Hillier, C., Berry, C., Petrie, M. C. et al. (2001) Effects of urotensin II in human arteries and veins of varying caliber. Circulation 103 , 13781381 5 Maguire, J. J., Kuc, R. E. and Davenport, A. P. (2000) Orphan-receptor ligand . . . . . . 65 Clinical Science (2003) 104 , 6567 (Printed in Great Britain) C O M M E N T Urotensin II: a new player in vascular and myocardial disease ? There has been considerable excitement and a flurry of contemporary research into the physiological actions of the 11-amino-acid peptide, urotensin II; however, urotensin II itself is not a new discovery. It was first described . . . . . . treatment modalities, and diabetic microangiopathy in patients with Type 2 diabetes mellitus. J. Diabetes Complications 15 , 150157 19 Moreau, P., dUscio, L. V., Shaw, S., Takase, H., Barton, M. and Luscher, T. F. (1997) Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET A -receptor antagonist. Circulation 96 , 19651991 20 Behm, D. J., Herold, C. L., Ohlstein, E. H., Knight, S. D., Dhanak, D. and Douglas, S. A. (2002) Pharmacological characterization of SB-710411 (Cpa- c [ D . . . --3000,5,300,3094,15568
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