Abstract: . . .  therefore be an indicator of endothelial function in vivo . The objective of the current study was to investigate whether the relationship between arterial diameters at retinal bifurcations differs in men with and without symptomatic peripheral vascular dis- ease (PVD). These individuals were matched for blood pressure (BP) and age in order to control for important known confounding factors. METHODS The study was carried out in accordance with . . .
. . .  optimal vascular topography: role of the endothelium. Basic Cardiol. Res. 86 (Suppl. 2), 8996 22 Chapman, N., Haimes, G., Stanton, A., Thom, S. and Hughes, A. (2000) Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects. Clin. Sci. 99 , 483488 # 2002 The Biochemical Society and the Medical Research Society Page 6 116 N. Chapman and others  . . .
. . .  Cooper, L. et al. (1999) Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study. Am. J. Epidemiol. 150 , 263270 13 Ginsberg, H. (2000) Insulin resistance and cardiovascular disease . J. Clin. Invest. 106 , 453458 14 Shimokawa, H. (1999) Primary endothelial dysfunction: atherosclerosis. J. Mol. Cell. Cardiol. 31 , 2337 15 Klein, R., Sharrett, A., Klein, B. et al. (2000) Are retinal arteriolar abnormalities . . .
. . .  muscle [28]. In conclusion, we have demonstrated differences in the retinal arteriolar network in a group of men with symptomatic PVD compared with healthy men matched for known confounding factors. This suggests that PVD is associated with abnormal endothelial function in the retinal microvasculature, and suggests the presence of a systemic abnormality of endothelial function in athero- sclerosis. ACKNOWLEDGMENTS This work was supported . . .
. . .  nature of endothelial dysfunction in atherosclerosis. Am. J. Cardiol. 75 , 71B74B 25 Zeiher, A., Drexler, H., Wollschlager, H. and Just, H. (1991) Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 83 , 391401 Received 20 September 2001/13 December 2001; accepted 12 April 2002 26 Celermajer, D., Sorensen, K., Bull, C., Robinson, J. and Deanfield, . . .
. . .  disease . J. Clin. Invest. 106 , 453458 14 Shimokawa, H. (1999) Primary endothelial dysfunction: atherosclerosis. J. Mol. Cell. Cardiol. 31 , 2337 15 Klein, R., Sharrett, A., Klein, B. et al. (2000) Are retinal arteriolar abnormalities related to atherosclerosis?: the Atherosclerosis Risk in Communities Study. Arterioscler. Thromb. Vasc. Biol. 20 , 16441650 16 Chapman, N., Baharudin, S., King, L., Thom, S., Hughes, A. and Stanton, A. (2000) Acute effects . . .
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