Abstract: . . .  least partially) reflect the 1634 NEUROLOGY 55 December (1 of 2) 2000 magnitude of an ischemic process that is indexed by the extent of WMSH, whereas hippocampal atrophy reflects yet another pathogenetic processes. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15.  . . .
. . .  related to the pathogenesis of dementia, as well as the magnitude of cortical gray matter atro- phy. Combined with pathophysiologic data in the lit- erature, these findings suggest that cortical gray matter atrophy may (at least partially) reflect the 1634 NEUROLOGY 55 December (1 of 2) 2000 magnitude of an ischemic process that is indexed . . .
. . .  partially) reflect the 1634 NEUROLOGY 55 December (1 of 2) 2000 magnitude of an ischemic process that is indexed by the extent of WMSH, whereas hippocampal atrophy reflects yet another pathogenetic processes. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16.  . . .
. . .  p < 0.007) and WMSH percent (increas- ing percent variance explained to 41.9%, p < 0.03); however, the proportion of variance explained by these predictor variables did not increase further when all three variables were used together. This suggests that within the lacune groups, the severity of cognitive impairment is most strongly associated with hippocampal volume reduc-  . . .
. . .  Asia Aging Study. Neurology 1999;53:337-343. Loeb C, Gandolfo C, Croce R, Conti M. Dementia associated with lacunar infarction. Stroke 1992;23:1225-1229. Tatemichi TK, Desmond DW, Paik M, et al. Clinical determi- nants of dementia related to stroke. Ann Neurol 1993;33:568- 575 . . .
. . .  ruled out. Although prefrontal cortex is considered to be the primary area of connectivity, widespread areas of posterior multimodal association cortex and hippocampus are also interconnected within cortical-subcortical Finally, tissue loss in neocortex might result from primary (albeit subclinical) ischemia. Occlusions of microvessels or chronic hypoperfusion might produce incomplete infarction (e.g., selective neuronal  . . .
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