Abstract: . . .  the endothelial cells of the vascular wall (a process that may be exacerbated if clearance is impaired). This leads to loss of vessel integrity and accumulation of A in the area surrounding the . . .
. . .  studies confirm that A generated by neurons accumulates in blood vessels following attempted clearance of excess A peptides. Thus, study of novel therapies that reduce the blood vessel- associated . . .
. . .  dementia, affects an estimated 4.5 million Americans according to the Alzheimers Association. Amyloid- (A) deposition is a hallmark of Alzheimers disease and other cerebral amyloid angiopathies. . . .
. . .  Alzheimers disease and other cerebral amyloid angiopathies. However, exactly how A accumulates and causes damage is not fully understood. In the first article, Cerebral microvascular A deposition . . .
. . .  Davis J, Otte-Hller I, Verbeek MM, Van Nostrand WE: Cerebral microvascular A deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant . . .
. . .  integrity and accumulation of A in the area surrounding the compromised vessel wall. Eventually, the damage is so great that the blood vessel deteriorates beyond functional use and new vessels form . . .
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