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Abstract: . . . million Americans Almost 6 million hospitalizations each year are due to cardiovascular disease Living with cardiovascular disease The 61 million Americans with some form of cardiovascular disease include those with high blood pressure coronary heart disease stroke congestive heart failure other conditions Economic impact of cardiovascular disease Estimated cost of cardiovascular disease in the United States in 2001 was $298 billion, including health care expenditures . . . . . . conctractile response in augmented Binding sites for digitalis glycosides on extracellular side of enzyme. Therapeutic levels of digitalis inhibit 10 to 30% of enzyme - toxic levels inhibit 50% Digitalis glycosides Indicated in cases of congestive heart failure Although some recent controversy as to whether it should be use in absence of atrial fibrillation Digitalis glycosides and blood pressure Mixed data on effect of blood pressure Standard believe was that glycosides increased blood pressure . . . . . . from 1775-1785 - first scientific study of a medicinal plant William Withering In 1785 Withering published the result of his research in a monograph An Account of the Foxglove, and Some of Its Medical Uses, with Practical Remarks on Dropsy, and Other Diseases Careful descriptions of his experiments on dosage and the results Digitalis purpurea Purple foxglove - an attractive biennial with large purple bell-shaped flowers in the Scrophulariaceae Often used as a garden ornamental Leaves contain . . . --1894,3,316,2141,9468
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